Combining Spravato With Therapy and Lifestyle Changes for Long-Term Mental Health

At The Pearl Institute, we believe that lasting mental wellness comes from more than a single treatment approach—it’s the result of integrating medical, psychological, and lifestyle support. While Spravato (esketamine) can offer meaningful relief for individuals facing treatment-resistant depression, true healing often deepens when it’s combined with therapy and intentional daily practices that nurture the mind and body.

How Does Esketamine Work?

Spravato, also known as esketamine, is an FDA-approved nasal spray designed for adults with treatment-resistant depression. Unlike traditional antidepressants that target serotonin or dopamine, esketamine works on the brain’s glutamate system, which is involved in learning, memory, and mood regulation. By stimulating new neural connections, Spravato can help patients experience a shift in perspective, creating space for hope and improved emotional balance.

Each Spravato session is administered under professional supervision in a controlled environment, ensuring comfort and safety throughout the process. While the treatment can help reduce depressive symptoms, understanding what to do after Spravato treatment is just as important as the treatment itself. That’s where therapy and lifestyle support play an essential role.

The Importance of Therapy Alongside Spravato

Spravato can open the door to healing—but therapy helps patients walk through it. The insights and emotional shifts that often follow Spravato sessions can be amplified through therapeutic integration. Working with a qualified therapist allows individuals to process new experiences, strengthen coping mechanisms, and build long-term emotional resilience.

At The Pearl Institute, we encourage combining Spravato with evidence-based therapies such as cognitive-behavioral therapy (CBT), mindfulness-based approaches, or trauma-informed care. These sessions help patients make sense of what arises during treatment and reinforce progress between visits. When medical and psychological care align, the potential for sustained improvement grows significantly.

Lifestyle Changes That Support Mental Wellness

While Spravato and therapy lay a strong foundation, day-to-day habits are the threads that hold mental health together. Consistent, mindful lifestyle choices can make a profound difference in maintaining balance after treatment.

We often recommend focusing on:

• Movement: Regular exercise boosts endorphins, energy, and emotional stability.

• Nutrition: Balanced meals rich in whole foods support both brain and body function.

• Sleep: Rest is essential for mood regulation and recovery.

• Connection: Building community—whether through friends, family, or support groups—helps prevent isolation.

• Mindfulness: Practices like journaling, yoga, or breathwork encourage presence and reduce stress.

These small, consistent changes not only complement Spravato therapy but also empower individuals to take an active role in their healing journey.

Building a Sustainable Routine

One of the most important aspects of long-term mental health is consistency. Establishing a daily or weekly rhythm that incorporates medication management, therapy sessions, and personal wellness routines helps patients maintain progress over time.

At The Pearl Institute, we guide each person in developing a routine that feels attainable and nurturing. Open communication with care providers ensures adjustments can be made as needs evolve. Over time, these steady habits help transform short-term relief into lasting wellness.

Long-Term Wellness Through Integration

True healing doesn’t come from a single intervention—it’s the result of integration. Combining esketamine Spravato for treatment-resistant depression with therapy and lifestyle changes creates a well-rounded holistic approach that supports both the brain’s biology and the individual’s daily life. This balance promotes deeper emotional health, resilience, and a renewed sense of self.

The Pearl Institute: Your Partner in Long-Term Healing

Located in Waynesville, NC, The Pearl Institute is dedicated to guiding individuals toward comprehensive, sustainable mental wellness. Our experienced team provides compassionate care and personalized treatment plans that combine medical expertise with emotional support.

Whether you’re considering beginning Spravato treatment or exploring what to do after Spravato treatment, our clinicians are here to help you navigate every step with understanding and respect. By integrating medication, therapy, and mindful lifestyle changes, The Pearl Institute empowers patients to move beyond symptom management and toward a life of lasting balance and purpose.

Ready to take the next step? Contact The Pearl Institute today to learn more about Spravato treatment and our integrative approach to long-term mental health.